Voet, Fundamentals of Biochemistry: Life at the Molecular Level, 5th Edition

Book Cover

Voet, Fundamentals of Biochemistry: Life at the Molecular Level, 5th Edition

By Donald Voet, Judith Voet, Charlotte Pratt

SINGLE-TERM
$69  USD | $89  CAN
MULTI-TERM
$119  USD | $139  CAN

Fundamentals of Biochemistry addresses the enormous advances in biochemistry, particularly in the areas of structural biology and bioinformatics, by providing a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. While continuing in its tradition of presenting complete and balanced coverage that is clearly presented and relevant to human health and disease, this version of Fundamentals of Biochemistry includes new pedagogy and enhanced visuals that provide a pathway for student learning.

WileyPLUS for Fundamentals of Biochemistry allows instructors to customize and tailor the course to meet their individual needs and provides a rich pathway for student understanding of the enormous advances in biochemistry. With bioinformatics exercises, animated process diagrams, and calculation videos to provide a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future.

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Hear from our Authors

Guided Tours

The Guided Tours, created by Charlotte Pratt, are multi-part animations that present big picture concepts conveyed through animations, tutorials, and practice.

Brief Bioinformatics Exercises

Short, assessable, and content-specific bioinformatics exercises serve as virtual hands-on assignments that illuminate the connections between theory and applied biochemistry, thereby stimulating student interest and proficiency in the subject.

Sample Calculation Videos

Students come to the course with different levels of math skills. These embedded videos provide sample calculations and step-by-step walkthroughs for key equations.

    Features Include:

  • Animated Process Diagrams: The many process diagrams in the course have each been broken down into discrete steps that students can navigate at their desired pace. These resources are intended to enrich the learning process for students, especially those who rely heavily on visual information. Whereas some resources, particularly the Animated Figures and Animated Process Diagrams, are brief and could easily be incorporated into an instructor’s classroom lecture, all the resources are ideal for student self-study, allowing students to proceed at their own pace or back up and review as needed. All the media resources are keyed to specific figures or sections, so students can explore molecular structures and processes as they work through a chapter.
  • Extended Bioinformatics Projects: A set of 12 newly updated exercises by Paul Craig, Rochester Institute of Technology, covering the contents and uses of databases related to nucleic acids, protein sequences, protein structures, enzyme inhibition, and other topics. The exercises use real data sets, pose specific questions, and prompt students to obtain information from online databases and to access the software tools for analyzing such data.
  • Focus on Evolution: An evolutionary tree icon marks content that illuminate examples of evolution at the biochemical level.
  • Reorganized and Expanded Problem Sets: End-of-chapter problems are now divided into two categories so that students and instructors can better assess lower- and higher-order engagement.

Donald Voet received his B.S. in chemistry from the California Institute of Technology in 1960 and a Ph.D. in chemistry from Harvard University in 1966 under the direction of William Lipscomb. He then did his postdoctoral research in the Biology Department at MIT with Alexander Rich. Upon completion of his postdoc in 1969, Dr. Voet became a faculty member in the Chemistry Department at the University of Pennsylvania where he taught a variety of biochemistry courses as well as general chemistry and X-ray crystallography. Dr. Voet’s research has focused on the x-ray crystallography of molecules of biological interest. He has been a visiting scholar at Oxford University, U.K., the University of California at San Diego, and the Weizmann Institute of Science in Israel. Dr. Voet is the coauthor of four previous editions of Fundamentals of Biochemistry (first published in 1999) as well as four editions of Biochemistry, a more advanced textbook (first published in 1990). Together with Judith G. Voet, Dr. Voet was co-editor-in-chief of the journal Biochemistry and Molecular Biology Education from 2000 to 2014. He has been a member of the Education Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and continues to be an invited speaker at numerous national and international venues. He, together with Judith G. Voet, received the 2012 award for Exemplary Contributions to Education from the American Society for Biochemistry and Molecular Biology (ASBMB). His hobbies include backpacking, scuba diving, skiing, travel, photography, and writing biochemistry textbooks.

Judith (“Judy”) Voet was educated in the New York City public schools, received her B.S. in chemistry from Antioch College, and her Ph.D. in biochemistry from Brandeis University under the direction of Robert H. Abeles. She did postdoctoral research at the University of Pennsylvania, Haverford College, and the Fox Chase Cancer Center. Dr. Voet’s main area of research involves enzyme reaction mechanisms and inhibition. She taught biochemistry at the University of Delaware before moving to Swarthmore College where she taught biochemistry, introductory chemistry, and instrumental methods for 26 years, reaching the position of James
H. Hammons Professor of Chemistry and Biochemistry and twice serving as department chair before going on “permanent sabbatical leave.” Dr. Voet has been a visiting scholar at Oxford University, U.K.; the University of California, San Diego; the University of Pennsylvania; and the Weizmann Institute of Science, Israel. She is a coauthor of four previous editions of Fundamentals of Biochemistry and four editions of the more advanced text, Biochemistry. Dr. Voet was co-editor-in-chief of the journal Biochemistry and Molecular Biology Education from 2000 to 2014. She has been a national councilor for the American Chemical Society (ACS) Biochemistry Division, a member of the Education and Professional Development Committee of the American Society for Biochemistry and Molecular Biology (ASBMB), and a member of the Education Committee of the International Union of Biochemistry and Molecular Biology (IUBMB). She, together with Donald Voet, received the 2012 award for Exemplary Contributions to Education from the ASBMB. Her hobbies include hiking, backpacking, scuba diving, tap dancing, and playing the Gyil (an African xylophone).

Charlotte Pratt received her B.S. in biology from the University of Notre Dame and her Ph.D. in biochemistry from Duke University under the direction of Salvatore Pizzo. Although she originally intended to be a marine biologist, she discovered that biochemistry offered the most compelling answers to many questions about biological structure-function relationships and the molecular basis for human health and disease. She conducted postdoctoral research in the Center for Thrombosis and Hemostasis at the University of North Carolina at Chapel Hill. She has taught at the University of Washington and currently teaches and supervises undergraduate researchers at Seattle Pacific University. Developing new teaching materials for the classroom and student laboratory is a long-term interest. In addition to working as an editor of several biochemistry textbooks, she has co-authored Essential Biochemistry and previous editions of Fundamentals of Biochemistry. When not teaching or writing, she enjoys hiking and gardening.

  1. Introduction to the Chemistry of Life
  2. Water
  3. Nucleotides, Nucleic Acids, and Genetic Information
  4. Amino Acids
  5. Proteins: Primary Structure
  6. Proteins: Three-Dimensional Structure
  7. Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies
  8. Carbohydrates
  9. Lipids and Biological Membranes
  10. Membrane Transport
  11. Enzymatic Catalysis
  12. Enzyme Kinetics, Inhibition, and Control
  13. Biochemical Signaling
  14. Introduction to Metabolism
  15. Glucose Catabolism
  16. Glycogen Metabolism and Gluconeogenesis
  17. Citric Acid Cycle
  18. Electron Transport and Oxidative Phosphorylation
  19. Photosynthesis (available online)
  20. Lipid Metabolism
  21. Amino Acid Metabolism
  22. Mammalian Fuel Metabolism: Integration and Regulation
  23. Nucleotide Metabolism
  24. Nucleic Acid Structure
  25. DNA Replication, Repair, and Recombination
  26. Transcription and RNA Processing
  27. Protein Synthesis
  28. Regulation of Gene Expression

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