Organic Chemistry, 12th Edition

Book Cover

Organic Chemistry, 12th Edition

By Graham Solomons, Craig Fryhle, and Scott Snyder

Organic Chemistry prepares students for success in the organic classroom and beyond by emphasizing the relationship between structure and reactivity. To accomplish this, the content is organized in a way that combines the most useful features of a functional group approach with one largely based on reaction mechanisms. The authors’ philosophy is to emphasize mechanisms and their common aspects as often as possible, and at the same time use the unifying features of functional groups as the basis for most sections. The structural aspects show students what organic chemistry is. Mechanistic aspects show students how it works. And wherever an opportunity arises, the authors show students what organic chemistry does in living systems and the physical world around us.

WileyPLUS for Organic Chemistry strikes the perfect balance between theory and practice with a combination of interactive concept maps, mechanism and reaction explorer practice, and video walkthroughs. Through an interactive approach, students learn how to put the pieces of organic chemistry together to solve problems.

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Hear from our Authors

Interactive Maps

Interactive Maps

Interactive Concept Maps let students test their knowledge of synthetic connections and summaries of reactions.

Step-by-Step Videos

Mechanism Walkthrough Videos review the mechanisms presented in each section, giving students extra visual guidance to help them master the concepts.

Solved Problem Videos

Solved Problem Videos demonstrate effective problem-solving strategies by walking students through solved in-text problems using audio and a whiteboard.

    What’s New

  • Video Mini Lectures: These videos focus on explaining challenging concepts from each chapter. They are perfect for flipped/hybrid classes or as a supplement to the traditional lecture.
  • Reaction, Mechanism, Synthesis Explorer Drills: Using Reaction Explorer, students complete reactions and get the necessary drill-and-practice to learn the correct steps along the way.
  • GO Tutorial Problems: Gradable questions with guided explanations help students understand the processes necessary for concept mastery.

T.W. Graham Solomons did his undergraduate work at The Citadel and received his doctorate in organic chemistry in 1959 from Duke University where he worked with C.K. Bradsher. Following this he was a Sloan Foundation Postdoctoral Fellow at the University of Rachester where he worked with V. Boekelheide. in 1960 he became a charter member of the faculty of the University of South Florida and became Professor of Chemistry in 1973. In 1992 he was made Professor Emeritus. His research interests have been in areas of heterocyclic chemistry and unusual aromatic compounds. He has published papers in the Journal of the American Chemical Society, the Journal of Organic Chemistry, and the Journal of Heterocyclic Chemistry. He has received several awards for distinguished teaching.

Craig B. Fryhle is Chair and Professor of Chemistry at Pacific Lutheran University. He earned his B.A. degree from Gettysburg College and Ph.D. from Brown University. His experiences at these institutions shaped his dedication to mentoring undergraduate students in chemistry and the liberal arts, which is a passion that burns strongly for him. His research interests have been in areas relating to the shikimic acid pathway, including molecular modeling and NMR spectrometry of substrates and analogues, as well as structure and reactivity studies of shikimate pathways enzymes using isotopic labeling and mass spectrometry.

Scott A. Snyder grew up in the suburbs of Buffalo NY and was an undergraduate at Williams College, where he graduated summa cum laude in 1999. He pursued his doctoral studies at The Scripps Research Institute in La Jolla CA under the tutelage of K. C. Nicolaou as an NSF, Pfizer, and Bristol-Myers Squibb predoctoral fellow. While there, he co-authored the graduate textbook Classics in Total Synthesis II with his doctoral mentor. Scott was then an NIH postdoctoral fellow with E. J. Corey at Harvard University. In 2006, Scott began his independent career at Columbia University, moved to The Scripps Research Institute on their Jupiter FL campus in 2013, and in 2015 assumed his current position as Professor of Chemistry at the University of Chicago. His research interests lie in the arena of natural products total synthesis, particularly in the realm of unique polyphenols, alkaloids, and halogenated materials. To date, he has trained more than 60 students at the high school, undergraduate, graduate, and postdoctoral levels and co-authored more than 50 research and review articles. Scott has received a number of awards and honors, including a Camille and Henry Dreyfus New Faculty Award, an Amgen Young Investigator Award, an Eli Lilly Grantee Award, a Bristol-Myers Squibb Unrestricted Grant Award, an Alfred P. Sloan Foundation Fellowship, a DuPont Young Professor Award, and an Arthur C. Cope Scholar Award from the American Chemical Society. He has also received awards recognizing his teaching, including a Cottrell Scholar Award from the Research Corporation for Science Advancement. He lives in Chicago with his wife Cathy and son Sebastian where he enjoys gardening, cooking, cycling, and watching movies.

1. The Basics: Bonding and Molecular Structure

2. Families of Carbon Compounds: Functional Groups, Intermolecular Forces, and Infrared (IR) Spectroscopy

3. Acids and Bases: An Introduction to Organic Reactions and Their Mechanisms

4. Nomenclature and Conformations of Alkanes and Cycloalkanes

Special Topic A. 13C NMR Spectroscopy – A Practical Introduction (online in WileyPLUS only)

5. Stereochemistry: Chiral Molecules

6. Nucleophilic Reactions: Properties and Substitution Reactions of Alkyl Halides

7. Alkenes and Alkynes I: Properties and Synthesis. Elimination Reactions of Alkyl Halides

8. Alkenes and Alkynes II: Addition Reactions

9. Nuclear Magnetic Resonance and Mass Spectrometry: Tools for Structure Determination

Special Topic B. NMR Theory and Instrumentation

10. Radical Reactions

Special Topic C. Chain-Growth Polymers (online in WileyPLUS only)

11. Alcohols and Ethers: Synthesis and Reactions

12. Alcohols from Carbonyl Compounds: Oxidation Reduction and Organometallic Compounds

Review Problem Set 1 (online in WileyPLUS only)

13. Conjugated Unsaturated Systems

14. Aromatic Compounds

Special Topic D. Electrocyclic and Cycloaddition Reactions (online in WileyPLUS only)

15. Reactions of Aromatic Compounds

16. Aldehydes and Ketones: Nucleophilic Addition to the Carbonyl Group

17. Carboxylic Acids and Their Derivatives: Nucleophilic Addition-Elimination at the Acyl Carbon

Special Topic E. Step-Growth Polymers (online in WileyPLUS only)

18. Reactions at the α Carbon of Carbonyl Compounds: Enols and Enolates

19. Condensation and Conjugate Addition Reactions of Carbonyl Compounds: More Chemistry of Enolates

Special Topic F. Thiols, Sulfur Ylides, and Disulfides (online in WileyPLUS only)

Special Topic G. Thiol Esters and Lipid Biosynthesis (online in WileyPLUS only)

20. Amines

Special Topic H. Alkaloids (online in WileyPLUS only)

21. Transition Metal Complexes: Promoters of Key Bond Forming Reactions
Review Problem Set 2 (online in WileyPLUS only)

22. Carbohydrates

23. Lipids

24. Amino Acids and Proteins

25. Nucleic Acids and Protein Synthesis

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